Using custom CA in python virtual environment

 You have installed your custom CA in your client machine. Using curl, everthing is fine(refer here).

But since your python script  use  virtenv, your script cannot see the custom CA.

This is because python virtualenv looking the certifcates in different place than the normal python 

$ python -c "import requests; print ( requests.certs.where() )"
/etc/ssl/certs/ca-certificates.crt

$ (.venv) python -c "import requests; print (requests.certs.where())" 
.../.venv/lib/python3.6/site-packages/certifi-2020.6.20-py3.6.egg/certifi/cacert.pem

Solution, is to import the custom CA to the virtual Environtment.

openssl x509 -in $specific_ca.crt -text >> $virtualenv/lib/python3.6/site-packages/certifi-2020.6.20-py3.6.egg/certifi/cacert.pem

ref:

https://stackoverflow.com/questions/34931378/certificate-verification-when-using-virtual-environments